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J

Junhu Fu

Fudan University

S

Shuyu Liang

Fudan University

W

Wutong Li

Fudan University

C

Chen Ma

Fudan University

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References (47)

[1]
FEAT: Full-Dimensional Efficient Attention Transformer for Medical Video Generation
2025Huihan Wang, Zhiwen Yang et al.
[2]
Prompt to Polyp: Medical Text-Conditioned Image Synthesis with Diffusion Models
2025Mikhail Chaichuk, Sushant Gautam et al.
[3]
A data-efficient strategy for building high-performing medical foundation models
2025Yuqi Sun, Weimin Tan et al.
[4]
Diverse Image Generation with Diffusion Models and Cross Class Label Learning for Polyp Classification
2025Vanshali Sharma, Debesh Jha et al.
[5]
Generative Inbetweening through Frame-wise Conditions-Driven Video Generation
2024Tianyi Zhu, Dongwei Ren et al.
[6]
CCIS-DIFF: A Generative Model with Stable Diffusion Prior for Controlled Colonoscopy Image Synthesis
2024Yifan Xie, Junchang Wang et al.
[7]
IPNet: An Interpretable Network With Progressive Loss for Whole-Stage Colorectal Disease Diagnosis
2024Junhu Fu, Ke Chen et al.
[8]
Bora: Biomedical Generalist Video Generation Model
2024Weixiang Sun, Xiaocao You et al.
[9]
SALI: Short-term Alignment and Long-term Interaction Network for Colonoscopy Video Polyp Segmentation
2024Qiang Hu, Zhenyu Yi et al.
[10]
ControlPolypNet: Towards Controlled Colon Polyp Synthesis for Improved Polyp Segmentation
2024Vanshali Sharma, Abhishek Kumar et al.
[11]
Endora: Video Generation Models as Endoscopy Simulators
2024Chenxin Li, Hengyu Liu et al.
[12]
Latte: Latent Diffusion Transformer for Video Generation
2024Xin Ma, Yaohui Wang et al.
[13]
ControlVideo: Training-free Controllable Text-to-Video Generation
2023Yabo Zhang, Yuxiang Wei et al.
[14]
Align Your Latents: High-Resolution Video Synthesis with Latent Diffusion Models
2023A. Blattmann, Robin Rombach et al.
[15]
MoStGAN-V: Video Generation with Temporal Motion Styles
2023Xiaoqian Shen, Xiang Li et al.
[16]
LDMVFI: Video Frame Interpolation with Latent Diffusion Models
2023Duolikun Danier, Fan Zhang et al.
[17]
Adding Conditional Control to Text-to-Image Diffusion Models
2023Lvmin Zhang, Anyi Rao et al.
[18]
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2022Jay Zhangjie Wu, Yixiao Ge et al.
[19]
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[20]
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Showing 20 of 47 references

Founder's Pitch

"ColoDiff generates dynamic-consistent and content-aware synthetic colonoscopy videos to aid in clinical diagnoses and data scarcity."

Medical AIScore: 7View PDF ↗

Commercial Viability Breakdown

0-10 scale

High Potential

2/4 signals

5

Quick Build

3/4 signals

7.5

Series A Potential

4/4 signals

10

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Why It Matters

This research is crucial for creating high-quality synthetic colonoscopy videos, addressing the scarcity of medical data which often hinders advanced diagnostic processes. By improving the availability and quality of synthetic medical videos, clinicians can perform better diagnostics especially in data-scare regions, ultimately leading to better disease management and patient outcomes.

Product Angle

ColoDiff can be productized as a tool within medical imaging software packages, offering hospitals and clinics an advanced feature for training and diagnosis augmentation. By addressing the data scarcity in clinical training and diagnostics, it complements current imaging technology and enhances clinician capabilities.

Disruption

ColoDiff could replace traditional augmentation techniques, offering a more reliable method for training and diagnosis validation without extensive real-world data collection. It also stands to disrupt companies focused on static medical imagery by offering dynamic and content-aware alternatives.

Product Opportunity

The medical imaging and diagnostics market is rapidly expanding, particularly in fields requiring high-difficulty diagnostics like gastroenterology. Hospitals and clinics aiming to enhance training capabilities and diagnostic accuracy may pay significant subscriptions for access to advanced synthetic data technologies like ColoDiff.

Use Case Idea

A medical software company could integrate ColoDiff into a platform for training endoscopists, providing realistic, diverse, and clinically varied synthetic colonoscopy scenarios.

Science

ColoDiff is a diffusion-based video generation framework designed specifically for colonoscopy videos. It uses a novel TimeStream module to maintain temporal consistency across video frames and a Content-Aware module to manage intra-frame content control. The system employs a non-Markovian sampling strategy for efficient real-time video generation. The model was tested across multiple datasets to validate its capabilities in generating clinically accurate synthetic videos.

Method & Eval

The framework was evaluated using three public datasets and an internal hospital database. It demonstrated improvements in disease diagnosis by 7.1% and segmentation Dice by 6.2% when synthetic data was included in training, showcasing strong performance improvements over existing models.

Caveats

The method relies on high-quality input data for effective video generation; poor initial datasets may result in less effective synthetic videos. Its success is contingent on integration into existing clinical workflows, which may require significant custom development and validation efforts.

Author Intelligence

Junhu Fu

Fudan University
jhfu21@m.fudan.edu.cn

Shuyu Liang

Fudan University
syliang22@m.fudan.edu.cn

Wutong Li

Fudan University
wtli22@m.fudan.edu.cn

Chen Ma

Fudan University
cma24@m.fudan.edu.cn

Peng Huang

Fudan University
phuang22@m.fudan.edu.cn

Kehao Wang

Fudan University
wang kehao@fudan.edu.cn

Zeju Li

Fudan University
zejuli@fudan.edu.cn

Yuanyuan Wang

Fudan University
yywang@fudan.edu.cn

Yi Guo

Fudan University
guoyi@fudan.edu.cn

Ke Chen

Fudan University Shanghai Cancer Center
kechen23@m.fudan.edu.cn

Shengli Lin

Zhongshan Hospital, Fudan University
lin.shengli@zs-hospital.sh.cn

Pinghong Zhou

Zhongshan Hospital, Fudan University
zhou.pinghong@zs-hospital.sh.cn