Accurate identification of protein active sites at the residue level is crucial for understanding protein function and advancing drug discovery. However, current methods face two critical challenges: ...
Protein language models (PLMs) are becoming practical tools for de novo protein design, yet their dual-use potential raises safety concerns. We show that domain adaptation to specific taxonomic groups...
The protein folding problem has been fundamentally transformed by artificial intelligence, evolving from static structure prediction toward the modeling of dynamic conformational ensembles and complex...